Personally, I have multiple strains and I usually mix 1tsp of each i choose and mix it the best I can in oj or punch but only 4-6 ounces. I take itv3-6 times a day. Only side effect myself or any of the more than dozen friends that have followed me have had is constipation which is just your body learning what to kee and what to throw away. This is only a tea leave and is all natural, which means fewer side effects. There's so many things this stuff helps to try and type it.