Surprised I haven't seen anyone mention the .243 yet. I like it and the .270 but it all depends on the terrain and shooter skill but if I had to choose one gun for the state it would be a bolt gun in .270 with a modest scope like 3-9 with AO.
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That link was a great read! Thanks for sharinghttp://www.dnr.sc.gov/wildlife/deer/articlegad.htmlOh, and the best all-around is a .260 Rem, or something very much like it, with a soft slightly heavy-for-caliber bullet.
Marlin 336 in .35 Rem or a 30-30