The Ruger MKIV comes apart with one button unlike all the ones before it.The Ruger is a good host but a bit of it comes down to the can too.
The annoying thing about the Ruger (that will probably catch me some heat) is that it's an utter pain in the azz to take down and clean, and - if you're a can fan - you're going to want to take it down and clean it. 22LR ammo is *dirty*.
I haven't shot one, even without a can - but one of the very few 22s that break the 10 round barrier would be the SIG P322 - which of course is nothing like a MK4, but comes with threaded barrel etc, and just went on my 'want' list.