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Some of the heavier .22-250 loads should not be over looked.
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Yet they will all day every day!.410 shotguns don't shoot 45 Colt pistol cartridges.
The chamber is the wrong dimension, and the bore on the shotgun is way too small.
Some handgun manufacturers have made handguns that are basically chambered for 45 colt cartridges with special modifications to allow them to also shoot .410 shotshells, but regular 410 shotguns can't do this.
She is just a spectator right now. Haven't gotten her one yetNate what did you go with?
300 blackout with the 110 Barnes bullet is excellent for deer hunting and anyone who says otherwise has never used them or can’t shoot.